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Publications and Abstracts

 

Below is a collection of peer-reviewed research papers and abstracts by Angarus scientists and our collaborators:

 
Featured
Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs

Li, L. et al. Nat. Chem. Biol. 10, 1043–1048 (2014).

STING polymer structure reveals mechanisms for activation, hyperactivation and inhibition

Ergun, SL, Fernandez, D., Weiss, T.M. and Li, L. Cell 178, 290–301 (2019)

SLC19A1 is an importer of the immunotransmitter cGAMP

Ritchie, C., Cordova, A. F., Hess, G. T., Bassik, M. C. & Li, L. Mol. Cell 75, 372–381 (2019).

Structural insights into STING signaling

Ergun, S.L. and Li, L. Trends in Cell Biol 30, 399-407 (2020).

Extracellular cGAMP is a cancer cell-produced immunotransmitter involved in radiation-induced anti-cancer immunity

Carozza JA, Böhnert V, Nguyen KC, Skariah G, Shaw KE, Brown JA, Rafat M, von Eyben R, Graves EE, Glenn JS, Smith M, Li L . Nat Cancer 1(2):184-196 (2020)

LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP

Lahey LJ, Mardjuki RE, Wen X, Hess GT, Ritchie C, Carozza JA, Böhnert V, Maduke M, Bassik MC, Li L . Mol Cell 80(4):578-591 (2020)

Human SLC46A2 Is the Dominant cGAMP Importer in Extracellular cGAMP-Sensing Macrophages and Monocytes

Cordova, A.F., Ritchie, C. Bohnert, V. and Li, L. ACS Cent Sci. 7(6):1073-1088 (2021)

cGAMP as an Adjuvant in Antiviral Vaccines and Cancer Immunotherapy

Ritchie C, Li L. Biochemistry. 2020 May 12; 59(18):1713-1715. doi: 10.1021/acs.biochem.0c00226. Epub 2020 Apr 17.

Development of cGAMP-Luc, a sensitive and precise coupled enzyme assay to measure cGAMP in complex biological samples.

Mardjuki RE, Carozza JA, Li L. J Biol Chem. 2020 Apr 10; 295(15):4881-4892. doi: 10.1074/jbc.RA119.012170. Epub 2020 Mar 3

The information in our publications and presentations should be considered accurate only as of the date of the publications or presentations. We disclaim any obligation to supplement or update the information in these publications and presentations.